2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. ART899

ART899 is a highly specific allosteric inhibitor of the Polθ DNA polymerase domain. ART899 can effectively enhance the radiosensitivity of tumor cells, shows good tolerance when combined with fractionated radiation, and significantly reduces tumor growth compared to radiation alone.

For research use only. We do not sell to patients.

ART899 Chemical Structure

ART899 Chemical Structure

CAS No. : 2607139-85-3

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Description

ART899 is a highly specific allosteric inhibitor of the Polθ DNA polymerase domain. ART899 can effectively enhance the radiosensitivity of tumor cells, shows good tolerance when combined with fractionated radiation, and significantly reduces tumor growth compared to radiation alone[1].

Molecular Weight

464.81

Formula

C19H13D3ClF4N3O4
CAS No.
SMILES

[2H]C([2H])([2H])N(C1=CC(Cl)=C(C=C1)F)C([C@H]2N(C3=CC(C(F)(F)F)=CC(C)=N3)C([C@H]([C@H]2O)O)=O)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ART899 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ART8992607139-85-3ART 899ART-899DNA/RNA SynthesisInhibitorinhibitorinhibit

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