2. Oligonucleotides
  3. Antisense Oligonucleotides
  4. ASO 556089 sodium

ASO 556089 sodium is a 16 nucleotide length gapmer (3-10-3) that targets the human and mouse long non-coding RNA MALAT1, with the sequence: 5’-GmCATTmCTAATAGmCAGmC-3’ .

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ASO 556089 sodium

ASO 556089 sodium Chemical Structure

Size Price Stock Quantity
1 mg USD 216 In-stock
5 mg USD 510 In-stock
10 mg USD 825 In-stock
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Based on 1 publication(s) in Google Scholar

ASO 556089 sodium Related Antibodies

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Description

ASO 556089 sodium is a 16 nucleotide length gapmer (3-10-3) that targets the human and mouse long non-coding RNA MALAT1, with the sequence: 5’-GmCATTmCTAATAGmCAGmC-3’ [1].

In Vitro

ASO 556089 (0.16-40 µM; 72 h) targeting PCSK9 and MALAT1 in 2D HRPTEC cultures[1].
ASO 556089 (1 and 10µM; 48 h) causes target transcriptional downregulation in HRTEC cultured on chip[1].
ASO 556089 (0.31-5 μM; 48 h) inhibits MALAT1 gene expression in 2D HRPTEC culture[1].
ASO 556089 (40 µM; 72 h) does not cause cytotoxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ASO 556089 sodium Related Antibodies
Molecular Weight

5414.60

Appearance

Solid

Color

White to off-white

SMILES

[ASO 556089 sodium]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (18.47 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.1847 mL 0.9234 mL 1.8469 mL
5 mM 0.0369 mL 0.1847 mL 0.3694 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 96.25%

COA (247 KB) LCMS (329 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.1847 mL 0.9234 mL 1.8469 mL 4.6171 mL
5 mM 0.0369 mL 0.1847 mL 0.3694 mL 0.9234 mL
10 mM 0.0185 mL 0.0923 mL 0.1847 mL 0.4617 mL
15 mM 0.0123 mL 0.0616 mL 0.1231 mL 0.3078 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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ASO 556089 sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ASO 556089ASO556089ASO-556089OthersInhibitorinhibitorinhibit

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