2. GPCR/G Protein Neuronal Signaling
  3. MCHR1 (GPR24) 5-HT Receptor
  4. ATC0065

ATC0065 is a potent, selective and orally active melanin-concentrating hormone (MCH) receptor 1 (MCHR1) antagonist with an IC50 of 15.7 nM for human MCHR1. ATC0065 does not exhibits significant activity for MCHR2. ATC0065 has anxiolytic and antidepressant activities.

For research use only. We do not sell to patients.

ATC0065 Chemical Structure

ATC0065 Chemical Structure

CAS No. : 510732-84-0

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Based on 1 publication(s) in Google Scholar

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Description

ATC0065 is a potent, selective and orally active melanin-concentrating hormone (MCH) receptor 1 (MCHR1) antagonist with an IC50 of 15.7 nM for human MCHR1. ATC0065 does not exhibits significant activity for MCHR2. ATC0065 has anxiolytic and antidepressant activities[1].

In Vitro

ATC0065 also exhibits high to moderate affinity for 5-HT2B and 5-HT1A receptors with IC50 values of 266 nM and 62.9 nM, reapectively.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ATC0065 Related Antibodies
In Vivo

ATC0065 (3-30 mg/kg; oral administration; 3 h prior to the test) shows antidepressant-like effects in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SpragueDawley rats (190-250 g) forced swimming[1]
Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg
Administration: Oral administration; 3 h prior to the test
Result: Significantly reduced immobility time in the forced swimming.
Molecular Weight

625.35

Formula

C25H31BrCl2F3N5O
CAS No.
SMILES

CN(C)C1=C2C=CC=CC2=NC(N[C@H]3CC[C@@H](NCCC4=CC=C(Br)C=C4OC(F)(F)F)CC3)=N1.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ATC0065 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATC0065510732-84-0ATC 0065ATC-0065MCHR1 (GPR24)5-HT ReceptorMelanin concentrating hormone receptor 1Serotonin Receptor5-hydroxytryptamine ReceptorMCHR1 antagonistanxiolytic and antidepressant activitiesorally activeInhibitorinhibitorinhibit

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HY-107626
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