ATR-IN-29

Cat. No.: HY-153729: FAQs
Data Sheet Handling Instructions

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ATR-IN-29 is a potent and orally active ATR kinase inhibitor with an IC₅₀ value of 1 nM. ATR-IN-29 shows antiproliferative activity.

For research use only. We do not sell to patients.

ATR-IN-29 Chemical Structure

CAS No. : 2761193-67-1

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ATM ATR

Biological Activity
Purity & Documentation
References
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Description

ATR-IN-29 is a potent and orally active ATR kinase inhibitor with an IC₅₀ value of 1 nM. ATR-IN-29 shows antiproliferative activity^[1].

IC₅₀ & Target^[1]

ATR

1 nM (IC₅₀)

In Vitro

ATR-IN-29 (compound 1) (4 days) shows antiproliferative activity with IC₅₀s of 156.70, 38.81, 22.48, 181.60, 19.02 nM for A549, HCC1806, HCT116, OVCAR-3, NCI-H460 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ATR-IN-29 (10 mg/kg; p.o.; once) shows good pharmacokinetic parameters with t_1/2 of 1.64 h, C_max of 9343 ng/mL, AUC_0-t of 98507 ng·h/mL, AUC_0-inf of 98517 ng·h/mL in CD-1 (ICR) mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

378.43

Formula

C₁₉H₂₂N₈O

CAS No.

2761193-67-1

SMILES

CC1=C2N(N=C(N3[C@@H](COCC3)C)C=C2C4=CC=NN4C)C(C5=NNC=C5)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sui Xiong Cai, et al. Substituted imidazo[1,5-b]pyridazine compounds as kinase inhibitors and use thereof. WO2022135560A1.

ATR-IN-29 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATR-IN-292761193-67-1ATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedInhibitorinhibitorinhibit

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