2. Protein Tyrosine Kinase/RTK
  3. TAM Receptor
  4. Axl-IN-17

Axl-IN-17 (compound 13c) is an orally active, selective AXL inhibitor with an IC50 value of 3.2 nM. Axl-IN-17 reveals antitumor efficacy.

For research use only. We do not sell to patients.

Axl-IN-17 Chemical Structure

Axl-IN-17 Chemical Structure

CAS No. : 3048409-80-6

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Axl-IN-17 Related Antibodies

Top Publications Citing Use of Products

View All TAM Receptor Isoform Specific Products:

View All Isoforms
Axl Mer Tyro3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Axl-IN-17 (compound 13c) is an orally active, selective AXL inhibitor with an IC50 value of 3.2 nM. Axl-IN-17 reveals antitumor efficacy[1].

IC50 & Target

Axl

 

Axl

3.23 nM (IC50)

Mer

 

Tyro3

 

In Vitro

Axl-IN-17 inhibits cancer-related kinases TYRO3, MER, MET, RON at 1 μM[1].
Axl-IN-17 exhibits antiproliferative activities in BaF3/TEL-AXL cell, with IC50 value <1 nM[1].
Axl-IN-17 (1 nM, 2 h) inhibits phosphorylation of AXL and its downstream signaling[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Axl-IN-17 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: BaF3/TEL-AXL
Concentration: 1 nM
Incubation Time: 72 h
Result: Inhibited proliferation activity in BaF3/TEL-AXL cells.

Western Blot Analysis[1]

Cell Line: BaF3/TEL-AXL
Concentration: 1 nM
Incubation Time: 2 h
Result: Inhibited phosphorylation of AXL and its downstream signaling
In Vivo

Axl-IN-17 (p.o.,3 mg/kg, once daily) reveals a T1/2 value of 10.09 h and an AUC value of 59815 ng•h/mL in pharmacokinetic study[1].
Axl-IN-17 (p.o.,25, 50 or 100 mg/kg, once daily for 7 days) exhibits antitumor efficacy in AXL-driven tumor xenograft mice[1].

Pharmacokinetic Analysis of AXL-IN-17 in Male Sprague-Dawley rats[1]

Route Dose (mg/kg) AUC0→∞ (ng·h/mL) T1/2 (h) Tmax (h) Cmax (ng/mL) MRT0→∞(h)
p.o. 3 mg/kg 59815 10.09 2 2906 16.5

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats /pharmacokinetic[1]
Dosage: 3 mg/kg (p.o.), once daily
Administration: Oral gavage
Result: Revealed a T1/2 value of 10.09 h and an AUC value of 59815 ng•h/mL.
Animal Model: BaF3/TEL-AXL xenograft mice[1]
Dosage: 25, 50 or 100 mg/kg, once daily for 7 days
Administration: Oral gavage
Result: Induced tumor regression.
Molecular Weight

563.60

Formula

C32H27F2N7O
CAS No.
SMILES

CC(C)N1C=C(C2=CC=C(F)C=C2)C(C3=C(NC4=CC(F)=C(C5=C(N)N=CC(C6=CN(C)N=C6)=C5)C=C4)N=CC=C31)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Axl-IN-17 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Axl-IN-173048409-80-6TAM ReceptorTyro3AxlMerreceptor tyrosine kinase AXLBaF3/TEL-AXLantitumorTYRO3MERMETRONInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Axl-IN-17
Cat. No.:
HY-162085
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.