Azido-PEG4-alpha-D-mannose

Name: Azido-PEG4-alpha-D-mannose
Brand: MedChemExpress
SKU: HY-141126
Rating: 4.5 (1 reviews)

Cat. No.: HY-141126 Purity: 96.24%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Azido-PEG4-alpha-D-mannose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-alpha-D-mannose is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

Azido-PEG4-alpha-D-mannose Chemical Structure

CAS No. : 1632372-86-1

Size	Price	Stock	Quantity
5 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

Azido-PEG4-alpha-D-mannose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. Azido-PEG4-alpha-D-mannose is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

381.38

Formula

C₁₄H₂₇N₃O₉

CAS No.

1632372-86-1

Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@H]1OCCOCCOCCOCCN=[N+]=[N-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 250 mg/mL (655.51 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6221 mL	13.1103 mL	26.2206 mL
5 mM	0.5244 mL	2.6221 mL	5.2441 mL
10 mM	0.2622 mL	1.3110 mL	2.6221 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 96.24%

Select Batch:

Data Sheet (267 KB) SDS (252 KB)

COA (243 KB) HNMR (247 KB) LCMS (85 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.6221 mL	13.1103 mL	26.2206 mL	65.5514 mL
	5 mM	0.5244 mL	2.6221 mL	5.2441 mL	13.1103 mL
	10 mM	0.2622 mL	1.3110 mL	2.6221 mL	6.5551 mL
	15 mM	0.1748 mL	0.8740 mL	1.7480 mL	4.3701 mL
	20 mM	0.1311 mL	0.6555 mL	1.3110 mL	3.2776 mL
	25 mM	0.1049 mL	0.5244 mL	1.0488 mL	2.6221 mL
	30 mM	0.0874 mL	0.4370 mL	0.8740 mL	2.1850 mL
	40 mM	0.0656 mL	0.3278 mL	0.6555 mL	1.6388 mL
	50 mM	0.0524 mL	0.2622 mL	0.5244 mL	1.3110 mL
	60 mM	0.0437 mL	0.2185 mL	0.4370 mL	1.0925 mL
	80 mM	0.0328 mL	0.1639 mL	0.3278 mL	0.8194 mL
	100 mM	0.0262 mL	0.1311 mL	0.2622 mL	0.6555 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.