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  3. Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane

Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane 

Cat. No.: HY-140874
Data Sheet Handling Instructions

Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane Chemical Structure

Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane Chemical Structure

CAS No. : 1421933-29-0

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Based on 1 publication(s) in Google Scholar

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Description

Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

778.93

Formula

C36H66N4O14

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)CCOCC(COCCC(OC(C)(C)C)=O)(COCCC(OC(C)(C)C)=O)NC(CCOCCOCCOCCOCCN=[N+]=[N-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane Related Classifications

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Product Name:
Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane
Cat. No.:
HY-140874
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