2. Epigenetics
  3. Epigenetic Reader Domain
  4. Balomenib

Balomenib is the inhibitor for menin-MLL interaction, that inhibits the interaction between men1-MLL4-43 with an IC50 < 0.075 μM. Balomenib inhibits the growth of MV4-11 (CC50 < 0.1 μM), MOLM-13 (CC50 0.1~0.5 μM) and HEK293 (CC50 < 2 μM). Balomenib exhibits antineoplastic activity.

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Balomenib Chemical Structure

Balomenib Chemical Structure

CAS No. : 2939850-17-4

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Description

Balomenib is the inhibitor for menin-MLL interaction, that inhibits the interaction between men1-MLL4-43 with an IC50 < 0.075 μM. Balomenib inhibits the growth of MV4-11 (CC50 < 0.1 μM), MOLM-13 (CC50 0.1~0.5 μM) and HEK293 (CC50 < 2 μM). Balomenib exhibits antineoplastic activity[1].

Molecular Weight

617.66

Formula

C33H34F3N7O2
CAS No.
SMILES

FC(F)(F)CC1=CC(C(N(C2)CC2(CC3)CCN3CC4=CC=C(N(C(C#N)=C5)C[C@@H]6CNC(CO6)=O)C5=C4C)=NC=N7)=C7C=C1
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Purity & Documentation
References
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Balomenib Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Balomenib2939850-17-4Epigenetic Reader DomainMV4-11MOLM-13HEK293Inhibitorinhibitorinhibit

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