2. Apoptosis
  3. Apoptosis Bcl-2 Family
  4. Bcl-2-IN-22

Bcl-2-IN-22 (compound 1) is a gold(I) NHC complex with anticancer activity. Bcl-2-IN-22 induces apoptosis via the mitochondrial pathway with an IC50 value of 0.014 μM. In addition, Bcl-2-IN-22 targets BCL-2 family members and exhibits pro-apoptosis and resensitization properties in multidrug-resistant leukemia cells that overexpress BCL?2.

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Bcl-2-IN-22 Chemical Structure

Bcl-2-IN-22 Chemical Structure

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Bcl-2-IN-22 Related Antibodies

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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Description

Bcl-2-IN-22 (compound 1) is a gold(I) NHC complex with anticancer activity. Bcl-2-IN-22 induces apoptosis via the mitochondrial pathway with an IC50 value of 0.014 μM. In addition, Bcl-2-IN-22 targets BCL-2 family members and exhibits pro-apoptosis and resensitization properties in multidrug-resistant leukemia cells that overexpress BCL?2[1].

Molecular Weight

956.76

Formula

C38H46AuF6N8P
SMILES

CC1=CC(C)=CC(C)=C1[N]2=NC([Au+]C3N=[N](C4=C(C)C=C(C)C=C4C)N=[N]3C5=C(C)C=C(C)C=C5C)[N](C6=C(C)C=C(C)C=C6C)=N2.[F-][P+5]([F-])([F-])([F-])([F-])[F-]
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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Bcl-2-IN-22 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bcl-2-IN-22ApoptosisBcl-2 FamilyAnticancerMitochondrial pathwayMultidrug resistanceLeukemia cellsResensitizationInhibitorinhibitorinhibit

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