2. Apoptosis Metabolic Enzyme/Protease
  3. Ferroptosis Glutathione Peroxidase
  4. BCP-T.A

BCP-T.A, a tunable heterocyclic electrophile, is a potent ferroptosis inducer by binding to GPX4. BCP-T.A is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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BCP-T.A Chemical Structure

BCP-T.A Chemical Structure

CAS No. : 2786829-70-5

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Based on 1 publication(s) in Google Scholar

BCP-T.A Related Antibodies

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Description

BCP-T.A, a tunable heterocyclic electrophile, is a potent ferroptosis inducer by binding to GPX4[1]. BCP-T.A is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

GPX4[1]
In Vitro

BCP-T.A induces ferroptosis in various cell lines (NCI-H522, T-1080, MDA-MB-468, MDA-MB-231, HeLa, HCT-116, U2OS, WI-38, and MEFS) with IC50 values of 10 nM-367 nM[1].
BCP-T.A (0.5 μM, 3 h) binds to GPX4 and increases lipid peroxides, indicated by cellular thermal shift assay (CETSA)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BCP-T.A Related Antibodies
Molecular Weight

456.39

Formula

C23H19Cl2N3OS
CAS No.
SMILES

O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C4=CSC(C#C)=N4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BCP-T.A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BCP-T.A2786829-70-5FerroptosisGlutathione PeroxidaseHeterocyclic electrophileCETSAlipid peroxidesInhibitorinhibitorinhibit

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