Berubicin hydrochloride  (Synonyms: RTA 744; WP 744; WP 769 hydrochloride)

Berubicin hydrochloride (RTA 744) is a Doxorubicin (HY-15142A) analogue. Berubicin hydrochloride triggers apoptosis and cell killing in NB cells by activating proapoptotic mediators. Berubicin hydrochloride has proapoptotic and anti-leukemia activities. Berubicin hydrochloride can be used for cancer research^[1][2][3].

Berubicin hydrochloride inhibits the activity of K562 cells with an IC₅₀ value of 0.18 mg/mL^[1].
Berubicin hydrochloride (0-100 µM; 24 h) inhibits thymidine absorption by KBM-5 cells^[2].
Berubicin hydrochloride (1 µM; 15 min) activates NF-κB by the p50 and p65 subunits of NF-κB in KBM-5 cells^[2].
Berubicin hydrochloride (0-100 µM; 72 h) inhibits Jurkat and RIP-deleted Jurkat cells proliferation in dose dependent manner^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

670.10

C₃₄H₃₆ClNO₁₁

293736-67-1

Solid

Brown to red

OC1=C2C([C@@]([H])(O[C@H]3C[C@H](N)[C@H](OCC4=CC=CC=C4)[C@H](C)O3)C[C@@](C(CO)=O)(O)C2)=C(O)C5=C1C(C6=CC=CC(OC)=C6C5=O)=O.Cl

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Faderl S, et al. WP744, a novel anthracycline with enhanced proapoptotic and antileukemic activity. Anticancer Res. 2001 Nov-Dec;21(6A):3777-84.  [Content Brief]

  [2]. Ashikawa K, et al. Evidence that activation of nuclear factor-kappaB is essential for the cytotoxic effects of doxorubicin and its analogues. Biochem Pharmacol. 2004 Jan 15;67(2):353-64.  [Content Brief]

  [3]. Wu J, Harris NL, Inge TH. Nuclear factor-kappa B and apoptosis inducing factor activation by doxorubicin analog WP744 in SH-SY5Y neuroblastoma cells. J Surg Res. 2004 Dec;122(2):231-9.  [Content Brief]