2. Epigenetics TGF-beta/Smad NF-κB Apoptosis
  3. PKC NF-κB Apoptosis
  4. BHA536

BHA536 is an orally active selective inhibitor for PKCα/β and NF-kB signaling pathway. BHA536 inhibits the proliferation of CD79-mutated ABC DLBCL cell, arrests cell cycle at G1 phase, and induces apoptosis in TMD8 cell. BHA536 exhibits antitumor efficacy in mice.

For research use only. We do not sell to patients.

BHA536 Chemical Structure

BHA536 Chemical Structure

CAS No. : 919992-85-1

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BHA536 Related Antibodies

Top Publications Citing Use of Products

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Description

BHA536 is an orally active selective inhibitor for PKCα/β and NF-kB signaling pathway. BHA536 inhibits the proliferation of CD79-mutated ABC DLBCL cell, arrests cell cycle at G1 phase, and induces apoptosis in TMD8 cell. BHA536 exhibits antitumor efficacy in mice[1].

Molecular Weight

548.03

Formula

C30H30ClN3O5
CAS No.
SMILES

CN(C)CC1=CC2=C(C=C1)C=CC(Cl)=C2C3=C(C4=CNC5=C4C=CC=C5OCCOCCOC)C(NC3=O)=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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BHA536 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BHA536919992-85-1BHA 536BHA-536PKCNF-κBApoptosisProtein kinase CNuclear factor-κBNuclear factor-kappaBDLBCLorally activeselectiveInhibitorinhibitorinhibit

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