BIBP3226

Cat. No.: HY-107726A: FAQs
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BIBP3226 is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with K_is of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 displays anxiogenic-like effect.

For research use only. We do not sell to patients.

BIBP3226 Chemical Structure

CAS No. : 159013-54-4

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View All Neuropeptide Y Receptor Isoform Specific Products:

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NPY Y₁ receptor NPY Y₂ receptor NPY Y₄ receptor NPY Y₅ receptor

Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
COS-1	EC₅₀	233 nM Compound: BIBP3226	Agonist activity at human NPFF2 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting Agonist activity at human NPFF2 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting	[PMID: 22708927]
SK-N-MC	IC₅₀	8.8 nM Compound: BIBP-3226	Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting	[PMID: 19916528]

In Vivo

BIBP3226 (0.5, 5 μg; i.c.v.; male Wistar rats) induces an anxiogenic-like effect at the higher dose^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

473.57

Formula

C₂₇H₃₁N₅O₃

CAS No.

159013-54-4

SMILES

O=C([C@@H](CCC/N=C(N)\N)NC(C(C1=CC=CC=C1)C2=CC=CC=C2)=O)NCC3=CC=C(C=C3)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mollereau C, et al. Agonist and antagonist activities on human NPFF(2) receptors of the NPY ligands GR231118 and BIBP3226. Br J Pharmacol. 2001 May;133(1):1-4. [Content Brief]

BIBP3226 Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BIBP3226159013-54-4BIBP 3226BIBP-3226Neuropeptide Y ReceptorNPY receptoranxiogenic-likeanxietybehaviorNPFFneuropeptideemotionalprocessesInhibitorinhibitorinhibit

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