Bifidenone

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Bifidenone is a tubulin polymerization inhibitor that exhibits antiproliferative activity against a range of human cancer cell lines.

For research use only. We do not sell to patients.

Bifidenone Chemical Structure

CAS No. : 2078008-57-6

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Description

Bifidenone is a tubulin polymerization inhibitor that exhibits antiproliferative activity against a range of human cancer cell lines^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	0.075 μM Compound: 2	Antiproliferative activity against human A375 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human A375 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
ACHN	IC₅₀	0.36 μM Compound: 2	Antiproliferative activity against human ACHN cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human ACHN cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
HCC 2998	IC₅₀	1.41 μM Compound: 2	Antiproliferative activity against human HCC2998 cells after 48 hrs by SRB assay Antiproliferative activity against human HCC2998 cells after 48 hrs by SRB assay	[PMID: 28335606]
M14	IC₅₀	0.064 μM Compound: 2	Antiproliferative activity against human M14 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human M14 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
M14	IC₅₀	0.11 μM Compound: 4a	Antiproliferative activity against human M14 cells after 72 hrs by CellTiter 96 aqueous nonradioactive cell proliferation assay Antiproliferative activity against human M14 cells after 72 hrs by CellTiter 96 aqueous nonradioactive cell proliferation assay	[PMID: 29995409]
Malme-3M	IC₅₀	< 0.1 μM Compound: 2	Antiproliferative activity against human MALME-3M cells after 48 hrs by SRB assay Antiproliferative activity against human MALME-3M cells after 48 hrs by SRB assay	[PMID: 28335606]
MDA-MB-435	IC₅₀	< 0.1 μM Compound: 2	Antiproliferative activity against human MDA-MB-435 cells after SRB assay Antiproliferative activity against human MDA-MB-435 cells after SRB assay	[PMID: 28335606]
NCI/ADR-RES	IC₅₀	0.17 μM Compound: 2	Antiproliferative activity against human NCI-ADR-RES cells after 48 hrs by SRB assay Antiproliferative activity against human NCI-ADR-RES cells after 48 hrs by SRB assay	[PMID: 28335606]
NCI-H460	IC₅₀	0.26 μM Compound: 4a	Antiproliferative activity against human NCI-H460 cells after 72 hrs by CellTiter 96 aqueous nonradioactive cell proliferation assay Antiproliferative activity against human NCI-H460 cells after 72 hrs by CellTiter 96 aqueous nonradioactive cell proliferation assay	[PMID: 29995409]
NCI-H460	IC₅₀	0.26 μM Compound: 2	Antiproliferative activity against human NCI-H460 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human NCI-H460 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
PC-3	IC₅₀	0.49 μM Compound: 2	Antiproliferative activity against human PC3 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human PC3 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
RAW264.7	IC₅₀	> 5 μM Compound: 2	Antiproliferative activity against mouse RAW264.7 cells after 18 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against mouse RAW264.7 cells after 18 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
SF-295	IC₅₀	0.25 μM Compound: 2	Antiproliferative activity against human SF295 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human SF295 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
SK-MEL-2	IC₅₀	0.095 μM Compound: 2	Antiproliferative activity against human SK-MEL-2 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human SK-MEL-2 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
SR	IC₅₀	< 0.1 μM Compound: 2	Antiproliferative activity against human SR cells after 48 hrs by SRB assay Antiproliferative activity against human SR cells after 48 hrs by SRB assay	[PMID: 28335606]
UACC-62	IC₅₀	0.044 μM Compound: 2	Antiproliferative activity against human UACC62 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human UACC62 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]

Molecular Weight

358.43

Formula

C₂₁H₂₆O₅

CAS No.

2078008-57-6

SMILES

O=C1C=C2OCO[C@]2(C[C@@H]1CC=C)[C@H](CC3=CC=C(C(OC)=C3)OC)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Huang Z, Williams RB, O'Neil-Johnson M, Eldridge GR, Mangette JE, Starks CM. A Total Synthesis of Bifidenone. J Org Chem. 2017 Apr 21;82(8):4235-4241. [Content Brief]

Bifidenone Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bifidenone2078008-57-6Microtubule/Tubulintubulin polymerizationantiproliferativecancer cell linesInhibitorinhibitorinhibit

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Bifidenone

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Bifidenone Related Classifications

Molarity Calculator

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