2. GPCR/G Protein
  3. Leukotriene Receptor
  4. BIIL-260

BIIL-260 is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist, with anti-inflammatory activity. BIIL-260 interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB4 receptor on isolated human neutrophil cell membranes with the Ki value of 1.7 nM.

For research use only. We do not sell to patients.

BIIL-260 Chemical Structure

BIIL-260 Chemical Structure

CAS No. : 204974-93-6

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BIIL-260 Related Antibodies

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LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

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Description

BIIL-260 is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist, with anti-inflammatory activity. BIIL-260 interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB4 receptor on isolated human neutrophil cell membranes with the Ki value of 1.7 nM[1].

IC50 & Target

Ki: 1.7 nM (LTB4 receptor)[1]
In Vitro

BIIL-260 potently inhibits LTB4-induced intracellular Ca2+ release in human neutrophils with the IC50 value of 0.82 nM.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BIIL-260 Related Antibodies
Molecular Weight

466.57

Formula

C30H30N2O3
CAS No.
SMILES

N=C(N)C1=CC=C(C=C1)OCC2=CC=CC(COC3=CC=C(C=C3)C(C4=CC=C(C=C4)O)(C)C)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BIIL-260 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BIIL-260204974-93-6BIIL260BIIL 260Leukotriene ReceptorInhibitorinhibitorinhibit

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HY-114641
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