BIIL-260

Cat. No.: HY-114641: FAQs
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BIIL-260 is a potent and long-acting orally active leukotriene B(4) receptor LTB₄ antagonist, with anti-inflammatory activity. BIIL-260 interacts with the LTB₄ receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB₄ receptor on isolated human neutrophil cell membranes with the K_i value of 1.7 nM.

For research use only. We do not sell to patients.

BIIL-260 Chemical Structure

CAS No. : 204974-93-6

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Other Forms of BIIL-260:

BIIL-260 hydrochloride Get quote

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LTB₄ LTC₄/CysLT₂ LTD₄/CysLT₁ LTE₄

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Description	BIIL-260 is a potent and long-acting orally active leukotriene B(4) receptor LTB₄ antagonist, with anti-inflammatory activity. BIIL-260 interacts with the LTB₄ receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB₄ receptor on isolated human neutrophil cell membranes with the K_i value of 1.7 nM^[1].
IC₅₀ & Target	Ki: 1.7 nM (LTB₄ receptor)^[1]
In Vitro	BIIL-260 potently inhibits LTB₄-induced intracellular Ca²⁺ release in human neutrophils with the IC₅₀ value of 0.82 nM. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. BIIL-260 Related Antibodies
Molecular Weight	466.57
Formula	C₃₀H₃₀N₂O₃
CAS No.	204974-93-6
SMILES	N=C(N)C1=CC=C(C=C1)OCC2=CC=CC(COC3=CC=C(C=C3)C(C4=CC=C(C=C4)O)(C)C)=C2
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (264 KB) Handling Instructions (2659 KB)
References	[1]. Birke FW, et al. In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist. J Pharmacol Exp Ther. 2001 Apr;297(1):458-66. [Content Brief]

BIIL-260 Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BIIL-260204974-93-6BIIL260BIIL 260Leukotriene ReceptorInhibitorinhibitorinhibit

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BIIL-260

Other Forms of BIIL-260:

BIIL-260 Related Antibodies

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