2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. BIMU 8

BIMU 8 is a potent and selective 5-HT4 agonist with EC50s of 18 nM, 77 nM, and 540 nM for wild type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4 receptors.

For research use only. We do not sell to patients.

BIMU 8 Chemical Structure

BIMU 8 Chemical Structure

CAS No. : 134296-40-5

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Based on 1 publication(s) in Google Scholar

BIMU 8 Related Antibodies

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  • Purity & Documentation

  • References

  • Customer Review

Description

BIMU 8 is a potent and selective 5-HT4 agonist with EC50s of 18 nM, 77 nM, and 540 nM for wild type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4 receptors[1][2].

IC50 & Target[2]

5-HT4 Receptor

18 nM (EC50)

T3.36A-5-HT4

77 nM (EC50)

W6.48A-5-HT4

540 nM (EC50)

In Vitro

In myenteric neurons of guinea pig ileum, BIMU 8 (0.003-0.1 µM) increases excitatory postsynaptic potentials (EPSPs) mplitude but does not change the membrane potential of any neuron[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BIMU 8 Related Antibodies
In Vivo

In mice and rats, BIMU 8 (20-30 mg/kg s.c. and 60 mg/kg p.o. in mice; 20 mg/kg i.p. in rats), produces significant antinociception. Intracerebroventricular injection in mice of BIMU 8 (10 μg/mouse), doses which are largely ineffective by parenteral routes, induces an antinociception whose intensity equaled that obtainable s.c., i.p. or p.o[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

377.89

Formula

C19H26ClN4O2-
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN([C@@H](CC1)C2)[C@H]1C[C@@H]2NC(N3C4=C(C=CC=C4)N(C(C)C)C3=O)=O.[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 37.79 mg/mL (100.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6463 mL 13.2314 mL 26.4627 mL
5 mM 0.5293 mL 2.6463 mL 5.2925 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6463 mL 13.2314 mL 26.4627 mL 66.1568 mL
5 mM 0.5293 mL 2.6463 mL 5.2925 mL 13.2314 mL
10 mM 0.2646 mL 1.3231 mL 2.6463 mL 6.6157 mL
15 mM 0.1764 mL 0.8821 mL 1.7642 mL 4.4105 mL
20 mM 0.1323 mL 0.6616 mL 1.3231 mL 3.3078 mL
25 mM 0.1059 mL 0.5293 mL 1.0585 mL 2.6463 mL
30 mM 0.0882 mL 0.4410 mL 0.8821 mL 2.2052 mL
40 mM 0.0662 mL 0.3308 mL 0.6616 mL 1.6539 mL
50 mM 0.0529 mL 0.2646 mL 0.5293 mL 1.3231 mL
60 mM 0.0441 mL 0.2205 mL 0.4410 mL 1.1026 mL
80 mM 0.0331 mL 0.1654 mL 0.3308 mL 0.8270 mL
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BIMU 8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BIMU 8134296-40-5BIMU8BIMU-85-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorantidepressantantinociception5-HT4EPSPInhibitorinhibitorinhibit

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