2. Autophagy Neuronal Signaling Metabolic Enzyme/Protease
  3. PINK1/Parkin E1/E2/E3 Enzyme
  4. BIO-2007817

BIO-2007817 is a Parkin positive allosteric modulators (PAMs). BIO-2007817 enhances the activity of wildtype Parkin. BIO-2007817 stimulates Parkin (an E3 ligase)autoubiquitination and induces the appearance of monoubiquitinated forms of Miro1 (EC50: 0.17 μM).

For research use only. We do not sell to patients.

BIO-2007817 Chemical Structure

BIO-2007817 Chemical Structure

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BIO-2007817 Related Antibodies

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Description

BIO-2007817 is a Parkin positive allosteric modulators (PAMs). BIO-2007817 enhances the activity of wildtype Parkin. BIO-2007817 stimulates Parkin (an E3 ligase)autoubiquitination and induces the appearance of monoubiquitinated forms of Miro1 (EC50: 0.17 μM)[1].

Molecular Weight

552.67

Formula

C32H36N6O3
SMILES

CO[C@@H](C1=CN(N=C1)C)C(N2CC3=C(C=NN3C[C@H]2C(C)C)C4=CC=C(C=C4)C(N5CCCC6=C5C=CC=C6)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BIO-2007817 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BIO-2007817BIO2007817BIO 2007817PINK1/ParkinE1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseInhibitorinhibitorinhibit

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