A disintegrin and metalloproteinase with thrombospondin motifs 13

Definition:

Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation.

References:

[1]. Masashi Akiyama, et al. Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19274-9. [Content Brief]

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