A-kinase anchor protein 9

Definition:

Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus. Required for microtubule nucleation at the cis-side of the Golgi apparatus. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery.; [Isoform 4]: Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations.

References:

[1]. Jingchao Wu, et al. Molecular Pathway of Microtubule Organization at the Golgi Apparatus. Dev Cell. 2016 Oct 10;39(1):44-60. [Content Brief]

[2]. Chao Yang, et al. EB1 and EB3 regulate microtubule minus end organization and Golgi morphology. J Cell Biol. 2017 Oct 2;216(10):3179-3198. [Content Brief]

[3]. M Cecilia Larocca, et al. AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus. Mol Biol Cell. 2004 Jun;15(6):2771-81. [Content Brief]

[4]. Shinya Ohta, et al. CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly. Mol Biol Cell. 2015 Apr 1;26(7):1225-37. [Content Brief]

[5]. Sabrina Rivero, et al. Microtubule nucleation at the cis-side of the Golgi apparatus requires AKAP450 and GM130. EMBO J. 2009 Apr 22;28(8):1016-28. [Content Brief]

[6]. O Witczak, et al. Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450. EMBO J. 1999 Apr 1;18(7):1858-68. [Content Brief]

[7]. Habib Bouguenina, et al. EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions. Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10687-E10696. [Content Brief]

[8]. J W Lin, et al. Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1. J Neurosci. 1998 Mar 15;18(6):2017-27. [Content Brief]

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