ABC-type organic anion transporter ABCA8

Definition:

[Isoform 1]: Catalyzes ATP-dependent import of organic anions such as taurocholate and estrone sulfate. In vitro, also imports ochratoxin A. Also mediates cholesterol efflux independent of apolipoprotein, and plays a role in sphingomyelin production in oligodendrocytes.; [Isoform 3]: Catalyzes ATP-dependent efflux of cholesterol and taurocholate. Interaction with ABCA1 potentiates cholesterol efflux to lipid-free APOA1, which regulates high-density lipoprotein cholesterol levels.

References:

[1]. Woojin Scott Kim, et al. ABCA8 stimulates sphingomyelin production in oligodendrocytes. Biochem J. 2013 Jun 15;452(3):401-10. [Content Brief]

[2]. Shuichi Tsuruoka, et al. Functional analysis of ABCA8, a new drug transporter. Biochem Biophys Res Commun. 2002 Oct 18;298(1):41-5. [Content Brief]

[3]. Laia Trigueros-Motos, et al. ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels. Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2147-2155. [Content Brief]

[4]. Kazunari Sasaki, et al. ATP-Binding Cassette Transporter A Subfamily 8 Is a Sinusoidal Efflux Transporter for Cholesterol and Taurocholate in Mouse and Human Liver. Mol Pharm. 2018 Feb 5;15(2):343-355. [Content Brief]

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