Acetylcholine receptor subunit alpha

Definition:

[Isoform 1]: Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.; [Isoform 2]: Non functional acetylcholine receptor alpha subunit which is not integrated into functional acetylcholine-gated cation-selective channels.

References:

[1]. C F Newland, et al. Functional and non-functional isoforms of the human muscle acetylcholine receptor. J Physiol. 1995 Dec 15;489 ( Pt 3)(Pt 3):767-78. [Content Brief]

[2]. Xin-Ming Shen, et al. Mutations Causing Slow-Channel Myasthenia Reveal That a Valine Ring in the Channel Pore of Muscle AChR is Optimized for Stabilizing Channel Gating. Hum Mutat. 2016 Oct;37(10):1051-9. [Content Brief]

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