Acid-sensing ion channel 3

Definition:

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.

References:

[1]. K Babinski, et al. Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties. J Neurochem. 1999 Jan;72(1):51-7. [Content Brief]

[2]. J R de Weille, et al. Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel. FEBS Lett. 1998 Aug 21;433(3):257-60. [Content Brief]

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