Actin nucleation-promoting factor WASL

Definition:

Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (By similarity). Plays a role in dendrite spine morphogenesis (By similarity). Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear.

References:

[1]. H Miki, et al. Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. Nature. 1998 Jan 1;391(6662):93-6. [Content Brief]

[2]. Olli Aitio, et al. Enterohaemorrhagic Escherichia coli exploits a tryptophan switch to hijack host f-actin assembly. Structure. 2012 Oct 10;20(10):1692-703. [Content Brief]

[3]. Xiaoyang Wu, et al. Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners. Nat Cell Biol. 2006 Jul;8(7):756-63. [Content Brief]

[4]. Tina Rajabian, et al. The bacterial virulence factor InlC perturbs apical cell junctions and promotes cell-to-cell spread of Listeria. Nat Cell Biol. 2009 Oct;11(10):1212-8. [Content Brief]

[5]. Jean-François Gaucher, et al. Interactions of isolated C-terminal fragments of neural Wiskott-Aldrich syndrome protein (N-WASP) with actin and Arp2/3 complex. J Biol Chem. 2012 Oct 5;287(41):34646-59. [Content Brief]

[6]. Juan Zhang, et al. Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with Wiskott-Aldrich syndrome protein. J Biol Chem. 2009 Aug 7;284(32):21659-69. [Content Brief]

[7]. Didier Vingadassalom, et al. Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation. Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6754-9. [Content Brief]

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