Actin-related protein 5

Definition:

Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.

References:

[1]. Kumiko Kitayama, et al. The human actin-related protein hArp5: nucleo-cytoplasmic shuttling and involvement in DNA repair. Exp Cell Res. 2009 Jan 15;315(2):206-17. [Content Brief]

[2]. Yingjun Jiang, et al. INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17274-9. [Content Brief]

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