Activating signal cointegrator 1 complex subunit 1

Definition:

Plays a role in DNA damage repair as component of the ASCC complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction.

References:

[1]. Dong-Ju Jung, et al. Novel transcription coactivator complex containing activating signal cointegrator 1. Mol Cell Biol. 2002 Jul;22(14):5203-11. [Content Brief]

[2]. Simon Almeida-Vega, et al. Gastrin activates paracrine networks leading to induction of PAI-2 via MAZ and ASC-1. Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G414-23. [Content Brief]

[3]. Jennifer M Soll, et al. RNA ligase-like domain in activating signal cointegrator 1 complex subunit 1 (ASCC1) regulates ASCC complex function during alkylation damage. J Biol Chem. 2018 Aug 31;293(35):13524-13533. [Content Brief]

[4]. Ellen Knierim, et al. Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures. Am J Hum Genet. 2016 Mar 3;98(3):473-489. [Content Brief]

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