Activating signal cointegrator 1

Definition:

Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation. Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. May play a role in the development of neuromuscular junction. May play a role in late myogenic differentiation (By similarity). Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation.

References:

[1]. Dong-Ju Jung, et al. Novel transcription coactivator complex containing activating signal cointegrator 1. Mol Cell Biol. 2002 Jul;22(14):5203-11. [Content Brief]

[2]. Hee Min Yoo, et al. Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development. Mol Cell. 2014 Oct 23;56(2):261-274. [Content Brief]

[3]. Satoshi Hashimoto, et al. Identification of a novel trigger complex that facilitates ribosome-associated quality control in mammalian cells. Sci Rep. 2020 Feb 25;10(1):3422. [Content Brief]

[4]. H J Kim, et al. Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation. Mol Cell Biol. 1999 Sep;19(9):6323-32. [Content Brief]

[5]. Ellen Knierim, et al. Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures. Am J Hum Genet. 2016 Mar 3;98(3):473-489. [Content Brief]

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