Adenine nucleotide translocator (ANT)

Definition:

Adenine nucleotide translocator (ANT) is a family of proteins involved in cell death pathways. ANT exchanges ATP with ADP between the intermembrane space to the matrix, and trigger the process of mitochondrial membrane permeabilization, which leads irreversibly to cell death.

References:

[1]. Brenner C, et al. Adenine nucleotide translocase family: four isoforms for apoptosis modulation in cancer. Oncogene. 2011 Feb 24;30(8):883-95. [Content Brief]

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