Adenylyl cyclase (AC)

Definition:

Adenylyl cyclases (ACs) are membrane bound enzymes that catalyze the production of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP) in response to the activation by G-protein Gαs. Different isoforms of ACs are ubiquitously expressed in different tissues involved in regulatory mechanisms in response to specific stimulants.

References:

[1]. Tatum Price, et al. Adenylyl cyclase 7 and neuropsychiatric disorders: A new target for depression? Pharmacol Res. 2019 May;143:106-112. [Content Brief]

[2]. Appalaraju Jaggupilli, et al. Study of adenylyl cyclase-GαS interactions and identification of novel AC ligands. Mol Cell Biochem. 2018 Sep;446(1-2):63-72. [Content Brief]

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