Adipogenesis regulatory factor

Definition:

Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin.

References:

[1]. Bradley J Scott, et al. APM2 is a novel mediator of cisplatin resistance in a variety of cancer cell types regardless of p53 or MMR status. Int J Cancer. 2009 Sep 1;125(5):1193-204. [Content Brief]

[2]. Yuhui Ni, et al. A Novel pro-adipogenesis factor abundant in adipose tissues and over-expressed in obesity acts upstream of PPARγ and C/EBPα. J Bioenerg Biomembr. 2013 Jun;45(3):219-28. [Content Brief]

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