Adiponectin receptor protein 2

Definition:

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).

References:

[1]. Hiroaki Tanabe, et al. Crystal structures of the human adiponectin receptors. Nature. 2015 Apr 16;520(7547):312-316. [Content Brief]

[2]. Toshimasa Yamauchi, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003 Jun 12;423(6941):762-9. [Content Brief]

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