ADP-ribosylation factor-like protein 1

Definition:

GTP-binding protein that recruits several effectors, such as golgins, arfaptins and Arf-GEFs to the trans-Golgi network, and modulates their functions at the Golgi complex. Plays thereby a role in a wide range of fundamental cellular processes, including cell polarity, innate immunity, or protein secretion mediated by arfaptins, which were shown to play a role in maintaining insulin secretion from pancreatic beta cells.

References:

[1]. Zhiqiu Man, et al. Arfaptins are localized to the trans-Golgi by interaction with Arl1, but not Arfs. J Biol Chem. 2011 Apr 1;286(13):11569-78. [Content Brief]

[2]. Antonio Galindo, et al. Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi. Cell Rep. 2016 Jul 19;16(3):839-50. [Content Brief]

[3]. Helmuth Gehart, et al. The BAR domain protein Arfaptin-1 controls secretory granule biogenesis at the trans-Golgi network. Dev Cell. 2012 Oct 16;23(4):756-68. [Content Brief]

[4]. Rong Wang, et al. Structural basis for targeting BIG1 to Golgi apparatus through interaction of its DCB domain with Arl1. J Mol Cell Biol. 2016 Oct 1;8(5):459-461. [Content Brief]

[5]. J X Hong, et al. Phospholipid- and GTP-dependent activation of cholera toxin and phospholipase D by human ADP-ribosylation factor-like protein 1 (HARL1). J Biol Chem. 1998 Jun 19;273(25):15872-6. [Content Brief]

[6]. Kensuke Nakamura, et al. Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase. J Biol Chem. 2012 Jul 20;287(30):25478-89. [Content Brief]

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