ADP-ribosylation factor-like protein 6-interacting protein 1

Definition:

Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (By similarity). Plays a role in the formation and stabilization of endoplasmic reticulum tubules. Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself. May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation.

References:

[1]. Yasunori Yamamoto, et al. Arl6IP1 has the ability to shape the mammalian ER membrane in a reticulon-like fashion. Biochem J. 2014 Feb 15;458(1):69-79. [Content Brief]

[2]. Hannah M Lui, et al. ARMER, apoptotic regulator in the membrane of the endoplasmic reticulum, a novel inhibitor of apoptosis. Mol Cancer Res. 2003 May;1(7):508-18. [Content Brief]

[3]. M Pettersson, et al. Characterization, chromosomal localization, and expression during hematopoietic differentiation of the gene encoding Arl6ip, ADP-ribosylation-like factor-6 interacting protein (ARL6). Genomics. 2000 Sep 15;68(3):351-4. [Content Brief]

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