AFG1-like ATPase

Definition:

Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress.

References:

[1]. Jana Cesnekova, et al. LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis. Oncotarget. 2016 Jul 26;7(30):47687-47698. [Content Brief]

[2]. Jana Cesnekova, et al. The mammalian homologue of yeast Afg1 ATPase (lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits. Biochem J. 2016 Mar 15;473(6):797-804. [Content Brief]

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