Akirin-1

Definition:

Molecular adapter that acts as a bridge between proteins, and which is involved skeletal muscle development (By similarity). Functions as signal transducer for MSTN during skeletal muscle regeneration and myogenesis (By similarity). May regulate chemotaxis of both macrophages and myoblasts by reorganising actin cytoskeleton, leading to more efficient lamellipodia formation via a PI3 kinase dependent pathway (By similarity). In contrast to AKIRIN2, not involved in nuclear import of proteasomes.

References:

[1]. Melanie de Almeida, et al. AKIRIN2 controls the nuclear import of proteasomes in vertebrates. Nature. 2021 Nov;599(7885):491-496. [Content Brief]

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