Aladin

Definition:

Plays a role in the normal development of the peripheral and central nervous system. Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment.

References:

[1]. A Tullio-Pelet, et al. Mutant WD-repeat protein in triple-A syndrome. Nat Genet. 2000 Nov;26(3):332-5. [Content Brief]

[2]. K Handschug, et al. Triple A syndrome is caused by mutations in AAAS, a new WD-repeat protein gene. Hum Mol Genet. 2001 Feb 1;10(3):283-90. [Content Brief]

[3]. Xin Li, et al. Molecular cloning and characterization of AAAS-V2, a novel splice variant of human AAAS. Mol Biol Rep. 2005 Jun;32(2):127-31. [Content Brief]

[4]. Sara Carvalhal, et al. The nucleoporin ALADIN regulates Aurora A localization to ensure robust mitotic spindle formation. Mol Biol Cell. 2015 Oct 1;26(19):3424-38. [Content Brief]

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