All-trans-retinol dehydrogenase [NAD

Definition:

Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives. Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives. Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal. Catalyzes in the oxidative direction with higher efficiency. Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation.

References:

[1]. M Hellgren, et al. Alcohol dehydrogenase 2 is a major hepatic enzyme for human retinol metabolism. Cell Mol Life Sci. 2007 Feb;64(4):498-505. [Content Brief]

[2]. Sílvia Martras, et al. Kinetics of human alcohol dehydrogenase with ring-oxidized retinoids: effect of Tween 80. Arch Biochem Biophys. 2004 Oct 15;430(2):210-7. [Content Brief]

[3]. S Svensson, et al. A novel subtype of class II alcohol dehydrogenase in rodents. Unique Pro(47) and Ser(182) modulates hydride transfer in the mouse enzyme. J Biol Chem. 1999 Oct 15;274(42):29712-9. [Content Brief]

[4]. Oriol Gallego, et al. Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids. Biochem J. 2006 Oct 1;399(1):101-9. [Content Brief]

[5]. Xixuan H Collins, et al. Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4. J Biol Chem. 2005 Sep 30;280(39):33157-64. [Content Brief]

[6]. A Allali-Hassani, et al. Retinoids, omega-hydroxyfatty acids and cytotoxic aldehydes as physiological substrates, and H2-receptor antagonists as pharmacological inhibitors, of human class IV alcohol dehydrogenase. FEBS Lett. 1998 Apr 24;426(3):362-6. [Content Brief]

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