Allergic rhinitis

Definition:

Allergic rhinitis (AR) is an inflammation of nasal mucosa mediated by IgE-associated processes, which is characterised by pruritus, sneezing, rhinorrhoea, and nasal congestion. The development of AR entails a complex interaction between genetic predisposition and environmental exposure to different factors, of which the most important is the implicated allergen. Single-nucleotide polymorphism studies involving genes encoding for molecules implicated in the pathogenesis of AR have also been made. Such molecules comprise chemokines and their receptors, interleukins and their receptors, eosinophil peroxidase and leukotrienes, among others.

References:

[1]. Alexander N Greiner, et al. Allergic rhinitis. Lancet. 2011 Dec 17;378(9809):2112-22. [Content Brief]

[2]. De-Yun Wang, et al. Risk factors of allergic rhinitis: genetic or environmental?. Ther Clin Risk Manag. 2005 Jun;1(2):115-23. [Content Brief]

[3]. Fulvio Braido, et al. Allergic rhinitis: current options and future perspectives. Curr Opin Allergy Clin Immunol. 2014 Apr;14(2):168-76. [Content Brief]

[4]. Ruby Pawankar, et al. Overview on the pathomechanisms of allergic rhinitis. Asia Pac Allergy. 2011 Oct;1(3):157-67. [Content Brief]

[5]. Sanjay N Mandhane, et al. Allergic rhinitis: an update on disease, present treatments and future prospects. Int Immunopharmacol. 2011 Nov;11(11):1646-62. [Content Brief]

[6]. Tania Mucci, et al. Allergic rhinitis. Mt Sinai J Med. 2011 Sep-Oct;78(5):634-44. [Content Brief]

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