Allosteric inhibitor

Definition:

Allosteric inhibitor is a kind of compound that binds to a distinct site on the surface of the enzyme or receptor, instead of the substrate-binding domain. Allosteric inhibitor offers a advantage in designing small-molecule inhibitors for lipid-metabolizing enzymes.

References:

[1]. Wenthur CJ,et al. Drugs for allosteric sites on receptors. Annu Rev Pharmacol Toxicol. 2014;54:165-84. [Content Brief]

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