Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

Definition:

Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAc-beta1,2-Man-alpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAc-beta1,2-Man-alpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway.

References:

[1]. Mika Kaneko, et al. A novel beta(1,6)-N-acetylglucosaminyltransferase V (GnT-VB)(1). FEBS Lett. 2003 Nov 20;554(3):515-9. [Content Brief]

[2]. Intaek Lee, et al. N-acetylglucosaminyltranferase VB expression enhances beta1 integrin- dependent PC12 neurite outgrowth on laminin and collagen. J Neurochem. 2006 May;97(4):947-56. [Content Brief]

[3]. Gerardo Alvarez-Manilla, et al. Comparison of the substrate specificities and catalytic properties of the sister N-acetylglucosaminyltransferases, GnT-V and GnT-Vb (IX). Glycobiology. 2010 Feb;20(2):166-74. [Content Brief]

[4]. Kei-ichiro Inamori, et al. Molecular cloning and characterization of human GnT-IX, a novel beta1,6-N-acetylglucosaminyltransferase that is specifically expressed in the brain. J Biol Chem. 2003 Oct 31;278(44):43102-9. [Content Brief]

[5]. Kei-ichiro Inamori, et al. N-Acetylglucosaminyltransferase IX acts on the GlcNAc beta 1,2-Man alpha 1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. J Biol Chem. 2004 Jan 23;279(4):2337-40. [Content Brief]

[6]. Karen L Abbott, et al. Integrin-dependent neuroblastoma cell adhesion and migration on laminin is regulated by expression levels of two enzymes in the O-mannosyl-linked glycosylation pathway, PomGnT1 and GnT-Vb. Exp Cell Res. 2006 Sep 10;312(15):2837-50. [Content Brief]

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