Alpha-globin transcription factor CP2

Definition:

Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.

References:

[1]. L C Lim, et al. Molecular cloning of the alpha-globin transcription factor CP2. Mol Cell Biol. 1992 Feb;12(2):828-35. [Content Brief]

[2]. Z Bing, et al. Purification and characterization of the serum amyloid A3 enhancer factor. J Biol Chem. 1999 Aug 27;274(35):24649-56. [Content Brief]

[3]. M K Shirra, et al. One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs. Mol Cell Biol. 1994 Aug;14(8):5076-87. [Content Brief]

[4]. S L Swendeman, et al. Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2. J Biol Chem. 1994 Apr 15;269(15):11663-71. [Content Brief]

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