Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial

Definition:

May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism (By similarity).

References:

[1]. Dragony Fu, et al. Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis. Genes Dev. 2013 May 15;27(10):1089-100. [Content Brief]

[2]. Guoqiang Wang, et al. The atomic resolution structure of human AlkB homolog 7 (ALKBH7), a key protein for programmed necrosis and fat metabolism. J Biol Chem. 2014 Oct 3;289(40):27924-36. [Content Brief]

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