Alternating hemiplegia of childhood

Definition:

Alternating hemiplegia of childhood (AHC) is a rare disorder with onset before 18 months of age. The earliest manifestations of AHC are recurrent bilateral attacks of hemiplegia lasting minutes to days, abnormal ocular movements, and autonomic disturbances. A characteristic feature of AHC is the disappearance of all abnormalities when the child falls asleep.

References:

[1]. B de Vries, et al. CACNA1A mutation linking hemiplegic migraine and alternating hemiplegia of childhood. Cephalalgia. 2008 Aug;28(8):887-91. [Content Brief]

[2]. B G R Neville, et al. The treatment and management of alternating hemiplegia of childhood. Dev Med Child Neurol. 2007 Oct;49(10):777-80. [Content Brief]

[3]. Hendrik Rosewich, et al. Heterozygous de-novo mutations in ATP1A3 in patients with alternating hemiplegia of childhood: a whole-exome sequencing gene-identification study. Lancet Neurol. 2012 Sep;11(9):764-73. [Content Brief]

[4]. M Bourgeois, et al. Alternating hemiplegia of childhood. J Pediatr. 1993 May;122(5 Pt 1):673-9. [Content Brief]

[5]. M T Bassi, et al. A novel mutation in the ATP1A2 gene causes alternating hemiplegia of childhood. J Med Genet. 2004 Aug;41(8):621-8. [Content Brief]

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