Ammonium transporter Rh type A

Definition:

Associated with rhesus blood group antigen expression. May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. Involved in ammonia transport across the erythrocyte membrane. Seems to act in monovalent cation transport.

References:

[1]. A M Marini, et al. The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast. Nat Genet. 2000 Nov;26(3):341-4. [Content Brief]

[2]. Andrew K Stewart, et al. Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S. Am J Physiol Cell Physiol. 2011 Dec;301(6):C1325-43. [Content Brief]

[3]. Connie M Westhoff, et al. Identification of the erythrocyte Rh blood group glycoprotein as a mammalian ammonium transporter. J Biol Chem. 2002 Apr 12;277(15):12499-502. [Content Brief]

[4]. L Tilley, et al. A new blood group system, RHAG: three antigens resulting from amino acid substitutions in the Rh-associated glycoprotein. Vox Sang. 2010 Feb;98(2):151-9. [Content Brief]

[5]. Sandrine Genetet, et al. Human RhAG ammonia channel is impaired by the Phe65Ser mutation in overhydrated stomatocytic red cells. Am J Physiol Cell Physiol. 2012 Jan 15;302(2):C419-28. [Content Brief]

[6]. Lesley J Bruce, et al. The monovalent cation leak in overhydrated stomatocytic red blood cells results from amino acid substitutions in the Rh-associated glycoprotein. Blood. 2009 Feb 5;113(6):1350-7. [Content Brief]

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