AMSH-like protease

Definition:

Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex. Does not cleave 'Lys-48'-linked polyubiquitin chains.

References:

[1]. Yusuke Sato, et al. Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains. Nature. 2008 Sep 18;455(7211):358-62. [Content Brief]

[2]. Dong Wang, et al. E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression. Mol Cell. 2022 Feb 17;82(4):770-784.e9. [Content Brief]

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