Anillin

Definition:

Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration.

References:

[1]. Makoto Kinoshita, et al. Self- and actin-templated assembly of Mammalian septins. Dev Cell. 2002 Dec;3(6):791-802. [Content Brief]

[2]. Aaron F Straight, et al. Anillin binds nonmuscle myosin II and regulates the contractile ring. Mol Biol Cell. 2005 Jan;16(1):193-201. [Content Brief]

[3]. Rasheed A Gbadegesin, et al. Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS. J Am Soc Nephrol. 2014 Sep;25(9):1991-2002. [Content Brief]

[4]. Tomomi Kiyomitsu, et al. Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase. Cell. 2013 Jul 18;154(2):391-402. [Content Brief]

[5]. K Oegema, et al. Functional analysis of a human homologue of the Drosophila actin binding protein anillin suggests a role in cytokinesis. J Cell Biol. 2000 Aug 7;150(3):539-52. [Content Brief]

[6]. Wei-Meng Zhao, et al. Anillin is a substrate of anaphase-promoting complex/cyclosome (APC/C) that controls spatial contractility of myosin during late cytokinesis. J Biol Chem. 2005 Sep 30;280(39):33516-24. [Content Brief]

[7]. Chie Suzuki, et al. ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3-kinase/AKT pathway. Cancer Res. 2005 Dec 15;65(24):11314-25. [Content Brief]

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