Ankyrin repeat and LEM domain-containing protein 1

Definition:

Endonuclease that probably plays a role in the DNA damage response and DNA repair.

References:

[1]. Andreas Brachner, et al. The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo. J Cell Sci. 2012 Feb 15;125(Pt 4):1048-57. [Content Brief]

[2]. Livija Zlopasa, et al. Nucleo-cytoplasmic shuttling of the endonuclease ankyrin repeats and LEM domain-containing protein 1 (Ankle1) is mediated by canonical nuclear export- and nuclear import signals. BMC Cell Biol. 2016 Jun 1;17(1):23. [Content Brief]

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