Ankyrin repeat domain-containing protein 17

Definition:

Could play pivotal roles in cell cycle and DNA regulation. Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways. Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too. Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).

References:

[1]. Yetao Wang, et al. Ankrd17 positively regulates RIG-I-like receptor (RLR)-mediated immune signaling. Eur J Immunol. 2012 May;42(5):1304-15. [Content Brief]

[2]. Min Deng, et al. Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17. J Biol Chem. 2009 Mar 20;284(12):7875-88. [Content Brief]

[3]. Maureen Menning, et al. A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses. FEBS Lett. 2013 Jul 11;587(14):2137-42. [Content Brief]

[4]. Wee M Yeo, et al. The VP1 structural protein of enterovirus 71 interacts with human ornithine decarboxylase and gene trap ankyrin repeat. Microb Pathog. 2007 Apr;42(4):129-37. [Content Brief]

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