Ankyrin repeat domain-containing protein 2

Definition:

Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress.

References:

[1]. Anna Belgrano, et al. Multi-tasking role of the mechanosensing protein Ankrd2 in the signaling network of striated muscle. PLoS One. 2011;6(10):e25519. [Content Brief]

[2]. Vittoria Cenni, et al. Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H(2)O(2). Mol Biol Cell. 2011 Aug 15;22(16):2946-56. [Content Brief]

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