Annexin A13

Definition:

[Isoform A]: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner. Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup.; [Isoform B]: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, but requires higher calcium levels for membrane binding than isoform A. Half-maximal membrane binding requires about 320 uM calcium.

References:

[1]. Sara Fernández-Lizarbe, et al. Structural and lipid-binding characterization of human annexin A13a reveals strong differences with its long A13b isoform. Biol Chem. 2017 Mar;398(3):359-371. [Content Brief]

[2]. Kathryn M McCulloch, et al. An alternative N-terminal fold of the intestine-specific annexin A13a induces dimerization and regulates membrane-binding. J Biol Chem. 2019 Mar 8;294(10):3454-3463. [Content Brief]

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