Anthrax toxin receptor 2

Definition:

Necessary for cellular interactions with laminin and the extracellular matrix.; (Microbial infection) Receptor for the protective antigen (PA) of B.anthracis. Binding of PA leads to heptamerization of the receptor-PA complex. Upon binding of the PA of B.anthracis, the complex moves to glycosphingolipid-rich lipid rafts, where it is internalized via a clathrin-dependent pathway. In the endosomal membrane, at pH under 7, the complex then rearranges and forms a pore allowing the other components of anthrax toxin to escape to the cytoplasm.

References:

[1]. S E Bell, et al. Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling. J Cell Sci. 2001 Aug;114(Pt 15):2755-73. [Content Brief]

[2]. Eugenio Santelli, et al. Crystal structure of a complex between anthrax toxin and its host cell receptor. Nature. 2004 Aug 19;430(7002):905-8. [Content Brief]

[3]. Heather M Scobie, et al. Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5170-4. [Content Brief]

[4]. Laurence Abrami, et al. Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process. J Cell Biol. 2003 Feb 3;160(3):321-8. [Content Brief]

[5]. Oonagh Dowling, et al. Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am J Hum Genet. 2003 Oct;73(4):957-66. [Content Brief]

[6]. Laurence Abrami, et al. Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway. J Cell Biol. 2004 Aug 30;166(5):645-51. [Content Brief]

[7]. D Borden Lacy, et al. Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation. Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13147-51. [Content Brief]

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